Allogeneic marrow grafting with partially mismatched, unrelated marrow donors
نویسندگان
چکیده
منابع مشابه
Allogeneic marrow grafting with partially mismatched, unrelated marrow donors.
Forty patients with advanced hematologic malignancies or severe aplastic anemia received marrow grafts from partially mismatched, unrelated marrow donors. All patients were administered conventional prophylaxis for acute graft-v-host disease (GVHD) consisting of methotrexate and low-dose glucocorticoids. All but two patients who survived at least 30 days showed durable engraftment. Six patients...
متن کاملUse of partially mismatched related donors extends access to allogeneic marrow transplant.
Most patients requiring allogeneic bone marrow transplant (allo-BMT) do not have an HLA-matched sibling donor. A phenotypically matched unrelated donor graft has been made available for approximately 50% of Caucasians and less than 10% of ethnic and racial minorities in need. However, almost all patients have a readily available partially mismatched related donor (PMRD). We summarize our experi...
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Medical advances have made bone marrow transplantation the treatment of choice for certain hematologic diseases. For those patients eligible for a marrow transplant only about 30 percent find an HLA-compatible match within their families. Studies indicate that unrelated volunteers are willing to donate their marrow. The National Marrow Donor Program was formed in 1986 as a result of a federal c...
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BACKGROUND Randomized trials have shown that the transplantation of filgrastim-mobilized peripheral-blood stem cells from HLA-identical siblings accelerates engraftment but increases the risks of acute and chronic graft-versus-host disease (GVHD), as compared with the transplantation of bone marrow. Some studies have also shown that peripheral-blood stem cells are associated with a decreased ra...
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There have been few reports on immune-mediated neurological disturbances and none on solitary occurrence of optic neuritis after bone marrow transplantation (BMT). We experienced a very rare case of immune-mediated optic neuritis as one symptom of graft-versus-host disease (GVHD). A 34-year-old man with chronic myelogenous leukemia in accelerated phase received BMT from a human leukocyte antige...
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ژورنال
عنوان ژورنال: Blood
سال: 1988
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v71.5.1375.1375